OPHTHALMOLOGY

The Corneal Cross-linking (CXL) is a parasurgical technique, born in Dresden in 1998. It’s based on a photodynamic polimerization process of the corneal stroma, which enhances its toughness by multiplying the collagen fibers, thus halting keratoconus.

During the years CXL evolved both in products and techniques: in this context SERVImed research and innovates products and devices, led by a technical staff and cooperating with academic, clinical and pharmaceutical figures.

CROSS-LINKING PRODUCTS

  • Servimed CF_X_Linker

CF X-LINKER

CE 1936 Corneal Cross-linking System

  • Ribocross Soluzione Oftalmica per Cross-linking Corneale

RIBOCROSS te

CE 0373 Ophthalmic solution for Corneal Cross-linking

  • RIBOFAST Soluzione Oftalmica per Cross-linking Corneale

RIBOFAST

CE 0373 Ophthalmic solution for Corneal Cross-linking

  • Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente, Gaetano Barbaro, Carmine Ostacolo, Salvatore Del Prete Evaluation of the penetration through human cornea of riboflavin 0.1% in solution with other molecules after trans-epithelial application. 1st EuCornea Congress, June 17-19 2010, Venice, Italy [pdf]
  • Robert L. Epstein, Salvatore Del Prete, Ciro Caruso, Salvatore Troisi, Carmine Ostacolo, Luigi Pacente, Antonio Del Prete, Gaetano Barbaro “Thickness and ultra-structural changes in keratoconus-affected human corneas after transepithelial cross-linking” American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073). [pdf]
  • Robert L. Epstein, Ciro Caruso, Carmine Ostacolo, Salvatore Troisi, Luigi Pacente, Gaetano Barbaro, Antonio Del Prete, Antonia Sacchi: “A new riboflavin solution for trans-epithelial cross-linking: a study of corneal pharmacokinetic” American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073). [pdf]
  • Salvatore Del Prete, Ciro Caruso, Luigi Pacente, Salvatore Troisi, Antonio Del Prete, Gaetano Barbaro “Effects of UV-A rays on the corneal epithelial surface after topical application of riboflavin solutions: an electron microscope study”. American Academy of Ophthalmology Annual Meeting, October 2010, Chicago (P0073) [pdf]
  • Carmine Ostacolo, Ciro Caruso, Diana Tronino, Salvatore Troisi, Sonia Laneri, Luigi Pacente, Antonio Del Prete, Antonia Sacchi “Increasing of corneal permeation of riboflavin-5′-phosphate through enhancers: A promising approach in corneal trans-epithelial cross-linking treatment” Inter J Pharm 440 (2013) 148– 153. [pdf]
  • Gaetano Barbaro, Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente “A Mathematical Model of Corneal UV-A Absorption After Soaking With a Riboflavin Solution During Trans-epithelial Cross-linking”. 1st Refractive Online and SICSSO Joint International Congress, July 7-9, 2011, Grosseto, Italy (Best paper, podium presentation) [pdf]
  • Ciro Caruso, Salvatore Troisi, Gaetano Barbaro, Carmine Ostacolo, Antonio Del Prete, Luigi Pacente “UV-A rays absorption in human corneas before and after trans-epithelial riboflavin application: an experimental study”. 2nd Refractive Online and SICSSO Joint International Congress, June 28-30, 2012, Rome, Italy (Podium presentation) [pdf]
  • Ciro Caruso, Salvatore Troisi, Antonio Del Prete, Luigi Pacente, Gaetano Barbaro “Trans-epithelial cross-linking with riboflavin solution: one-year clinical results”. 1st Refractive Online and SICSSO Joint International Congress, July 7-9, 2011, Grosseto, Italy (Podium presentation) [pdf]
  • Ciro Caruso, Luigi Pacente, Robert L. Epstein, Salvatore Troisi, Gaetano Barbaro, Antonio Del Prete: “Trans-epithelial cross-linking with riboflavin solution: two-year clinical results” 2nd joint International Congress Refractive Online & SICSSO, Rome 2012 (podium presentation).[pdf]
  • Ciro Caruso, Carmine Ostacolo, Robert L. Epstein, Gaetano Barbaro, Salvatore Troisi, Decio Capobianco: “Transepithelial Corneal Cross-Linking With Vitamin E-Enhanced Riboflavin Solution and Abbreviated, Low-Dose UV-A: 24-Month Clinical Outcomes” Cornea 2016;35:145–150. [pdf]
  • Ciro Caruso, Gaetano Barbaro, Robert L. Epstein, Diana Tronino, Carmine Ostacolo, Antonia Sacchi, Luigi Pacente, Antonio Del Prete, Marina Sala, Salvatore Troisi: “Corneal Cross-Linking: Evaluating the Potential for a Lower Power, Shorter Duration Treatment” Cornea 2016;35:659–662. [pdf]
  • Ciro Caruso, Robert L. Epstein, Carmine Ostacolo, Luigi Pacente, Salvatore Troisi, Gaetano Barbaro. “Customized Corneal Cross-linking – A Mathematical Model” Cornea 2017; 36:600–604 [pdf]

2018-04-17T19:11:50+00:00 9 March 2015|CROSS-LINKING|